Overview
DSIP has been described as a sleep-promoting substance rather than a sedative.
There is a modulating effect on sleep and wake functions with a greater activity in circumstances where sleep is disturbed.
There are minimal effects in healthy subjects who are not suffering from sleep disturbances, DSIP is not a night sedation drug which needs to be given just before retiring.
A dose of DSIP given during the day will promote improved sleep on the next night and for several nights thereafter.
DSIP promotes sleep, concentrations of DSIP are lower in the mornings and higher in the afternoons.
An elevation of endogenous DSIP concentration has been reported to be associated with suppression of both slow-wave sleep and rapid-eye movement sleep and interestingly also with body temperature, plasma concentrations of DSIP are influenced by the initiation of sleep.
Indications/Uses
- Sleep promotion
- Neuroprotection
- Alcohol/drug detoxification and withdrawal
Dosage
SQ (100 mcg) daily 3 hours before bedtime.
Warnings and Cautions
Sedation in the classical pharmacological sense is not seen with DSIP.
Administration of synthetic DSIP does not induce tolerance.
Side effects are minimal, but may include:
- Transient headache
- Nausea/vomiting
- Vertigo
